| League Schedule |
| Week 1 |
| Matchup | Date/Score |
| Alta Loma at Arizona | -2 1/2 |
| Woodbridge at Motor City | -3 |
| Las Vegas at Pripyat | -6 |
| St. Louis at Des Moines | +13 1/2 |
| Michiana at Slippery Rock | +2 1/2 |
| Utica at Pittsburgh | +14 1/2 |
| Goose Bay at Phoenix | +4 1/2 |
| St. Paul at Flagstaff | - 2 1/2 |
| Los Angeles at Southern | - 7 |
| Minnesota at Staten Island | +6 1/2 |
| Week 2 |
| Matchup | Date/Score |
| Las Vegas at St. Louis | 9/19/2010 |
| Des Moines at Arizona | 9/19/2010 |
| Slippery Rock at Woodbridge | 9/19/2010 |
| Southern at Goose Bay | 9/19/2010 |
| St. Paul at Utica | 9/19/2010 |
| Alta Loma at Phoenix | 9/19/2010 |
| Minnesota at Motor City | 9/19/2010 |
| Michiana at Flagstaff | 9/19/2010 |
| Pittsburgh at Staten Island | 9/19/2010 |
| Los Angeles at Pripyat | 9/19/2010 |
| Week 3 |
| Matchup | Date/Score |
| Phoenix at Los Angeles | 9/26/2010 |
| Goose Bay at Arizona | 9/26/2010 |
| Woodbridge at Staten Island | 9/26/2010 |
| St. Louis at Alta Loma | 9/26/2010 |
| Pripyat at Des Moines | 9/26/2010 |
| Las Vegas at Southern | 9/26/2010 |
| St. Paul at Slippery Rock | 9/26/2010 |
| Motor City at Michiana | 9/26/2010 |
| Utica at Minnesota | 9/26/2010 |
| Flagstaff at Pittsburgh | 9/26/2010 |
| Week 4 |
| Matchup | Date/Score |
| Michiana at Minnesota | 10/3/2010 |
| Arizona at Pripyat | 10/3/2010 |
| Las Vegas at Goose Bay | 10/3/2010 |
| Motor City at Utica | 10/3/2010 |
| Phoenix at St. Louis | 10/3/2010 |
| Southern at Slippery Rock | 10/3/2010 |
| Des Moines at Pittsburgh | 10/3/2010 |
| Staten Island at Flagstaff | 10/3/2010 |
| Los Angeles at Alta Loma | 10/3/2010 |
| St. Paul at Woodbridge | 10/3/2010 |
| Week 5 |
| Matchup | Date/Score |
| St. Louis at Pripyat | 10/10/2010 |
| Arizona at Southern | 10/10/2010 |
| Los Angeles at Des Moines | 10/10/2010 |
| Goose Bay at Alta Loma | 10/10/2010 |
| Michiana at Pittsburgh | 10/10/2010 |
| Utica at Flagstaff | 10/10/2010 |
| Woodbridge at Minnesota | 10/10/2010 |
| Phoenix at Motor City | 10/10/2010 |
| Staten Island at Slippery Rock | 10/10/2010 |
| Las Vegas at St. Paul | 10/10/2010 |
| Week 6 |
| Matchup | Date/Score |
| Pripyat at Flagstaff | 10/17/2010 |
| Las Vegas at Des Moines | 10/17/2010 |
| Goose Bay at Los Angeles | 10/17/2010 |
| Alta Loma at Minnesota | 10/17/2010 |
| Woodbridge at Michiana | 10/17/2010 |
| Motor City at Slippery Rock | 10/17/2010 |
| Phoenix at Southern | 10/17/2010 |
| St. Paul at Pittsburgh | 10/17/2010 |
| St. Louis at Arizona | 10/17/2010 |
| Utica at Staten Island | 10/17/2010 |
| Week 7 |
| Matchup | Date/Score |
| Southern at St. Louis | 10/24/2010 |
| Slippery Rock at Utica | 10/24/2010 |
| Alta Loma at Las Vegas | 10/24/2010 |
| Staten Island at Michiana | 10/24/2010 |
| Flagstaff at Motor City | 10/24/2010 |
| Pittsburgh at Woodbridge | 10/24/2010 |
| Des Moines at Goose Bay | 10/24/2010 |
| Minnesota at St. Paul | 10/24/2010 |
| Arizona at Los Angeles | 10/24/2010 |
| Pripyat at Phoenix | 10/24/2010 |
| Week 8 |
| Matchup | Date/Score |
| Phoenix at Arizona | 10/31/2010 |
| Motor City at Staten Island | 10/31/2010 |
| St. Louis at Utica | 10/31/2010 |
| Las Vegas at Los Angeles | 10/31/2010 |
| St. Paul at Michiana | 10/31/2010 |
| Goose Bay at Woodbridge | 10/31/2010 |
| Alta Loma at Des Moines | 10/31/2010 |
| Minnesota at Pittsburgh | 10/31/2010 |
| Pripyat at Southern | 10/31/2010 |
| Flagstaff at Slippery Rock | 10/31/2010 |
| Week 9 |
| Matchup | Date/Score |
| Southern at Alta Loma | 11/7/2010 |
| Los Angeles at St. Louis | 11/7/2010 |
| Flagstaff at Woodbridge | 11/7/2010 |
| Slippery Rock at Minnesota | 11/7/2010 |
| Arizona at Las Vegas | 11/7/2010 |
| Des Moines at Phoenix | 11/7/2010 |
| Pripyat at Goose Bay | 11/7/2010 |
| Pittsburgh at Motor City | 11/7/2010 |
| Michiana at Utica | 11/7/2010 |
| Staten Island at St. Paul | 11/7/2010 |
| Week 10 |
| Matchup | Date/Score |
| Des Moines at Flagstaff | 11/14/2010 |
| Pittsburgh at Pripyat | 11/14/2010 |
| Minnesota at Los Angeles | 11/14/2010 |
| Alta Loma at Michiana | 11/14/2010 |
| Woodbridge at Las Vegas | 11/14/2010 |
| Phoenix at Utica | 11/14/2010 |
| Staten Island at Southern | 11/14/2010 |
| Arizona at Slippery Rock | 11/14/2010 |
| Motor City at St. Louis | 11/14/2010 |
| Goose Bay at St. Paul | 11/14/2010 |
| Week 11 |
| Matchup | Date/Score |
| Slippery Rock at Des Moines | 11/21/2010 |
| Pittsburgh at Southern | 11/21/2010 |
| Minnesota at Pripyat | 11/21/2010 |
| St. Paul at Phoenix | 11/21/2010 |
| Flagstaff at Alta Loma | 11/21/2010 |
| Woodbridge at St. Louis | 11/21/2010 |
| Staten Island at Los Angeles | 11/21/2010 |
| Utica at Goose Bay | 11/21/2010 |
| Michiana at Arizona | 11/21/2010 |
| Motor City at Las Vegas | 11/21/2010 |
| Week 12 |
| Matchup | Date/Score |
| Arizona at Phoenix | 11/28/2010 |
| Southern at Pripyat | 11/28/2010 |
| Michiana at St. Paul | 11/28/2010 |
| Slippery Rock at Flagstaff | 11/28/2010 |
| St. Louis at Goose Bay | 11/28/2010 |
| Staten Island at Motor City | 11/28/2010 |
| Des Moines at Alta Loma | 11/28/2010 |
| Los Angeles at Las Vegas | 11/28/2010 |
| Pittsburgh at Minnesota | 11/28/2010 |
| Utica at Woodbridge | 11/28/2010 |
| Week 13 |
| Matchup | Date/Score |
| Motor City at Flagstaff | 12/5/2010 |
| Arizona at Staten Island | 12/5/2010 |
| Las Vegas at Alta Loma | 12/5/2010 |
| Los Angeles at Michiana | 12/5/2010 |
| Goose Bay at Des Moines | 12/5/2010 |
| St. Louis at Southern | 12/5/2010 |
| Woodbridge at Pittsburgh | 12/5/2010 |
| Utica at Slippery Rock | 12/5/2010 |
| St. Paul at Minnesota | 12/5/2010 |
| Phoenix at Pripyat | 12/5/2010 |
| Week 14 |
| Matchup | Date/Score |
| Slippery Rock at Motor City | 12/12/2010 |
| Flagstaff at Minnesota | 12/12/2010 |
| Southern at Phoenix | 12/12/2010 |
| Los Angeles at Goose Bay | 12/12/2010 |
| Des Moines at Las Vegas | 12/12/2010 |
| Michiana at Woodbridge | 12/12/2010 |
| Pripyat at Alta Loma | 12/12/2010 |
| Arizona at St. Louis | 12/12/2010 |
| Pittsburgh at St. Paul | 12/12/2010 |
| Staten Island at Utica | 12/12/2010 |
| Week 15 |
| Matchup | Date/Score |
| Pripyat at St. Louis | 12/19/2010 |
| Des Moines at Los Angeles | 12/19/2010 |
| Alta Loma at Goose Bay | 12/19/2010 |
| Flagstaff at Utica | 12/19/2010 |
| Phoenix at Las Vegas | 12/19/2010 |
| Minnesota at Woodbridge | 12/19/2010 |
| Slippery Rock at Staten Island | 12/19/2010 |
| Motor City at St. Paul | 12/19/2010 |
| Pittsburgh at Michiana | 12/19/2010 |
| Southern at Arizona | 12/19/2010 |
| Week 16 |
| Matchup | Date/Score |
| Utica at Motor City | 12/26/2010 |
| Flagstaff at Staten Island | 12/26/2010 |
| Minnesota at Michiana | 12/26/2010 |
| Woodbridge at St. Paul | 12/26/2010 |
| Goose Bay at Las Vegas | 12/26/2010 |
| Alta Loma at Los Angeles | 12/26/2010 |
| St. Louis at Phoenix | 12/26/2010 |
| Pripyat at Arizona | 12/26/2010 |
| Slippery Rock at Pittsburgh | 12/26/2010 |
| Southern at Des Moines | 12/26/2010 |
